The Man Who Can’t Die is a literary thriller set in 2180. When Dr. Ruth Bryson invents Paregane, a Euphoric drug that cures ennui and depression, Monozone Inc. is thrilled. The world is suffering from epidemic despair and apathy, and Paregane appears to be a panacea. There is only one problem. It kills 10% of everyone who takes it. Monozone decides to market it anyway, despite Bryson’s objections, and puts her former lover Owen Bradlee in charge. Bryson knows she must either fix Paregane or stop it, but if she is caught she will certainly be killed.

Felix and Veronica Clay are typical pod-dwelling office workers, whose lives seem like an endless extenuation of meaningless circumstance. When Veronica plunges into psychosis and tries to kill herself, her doctorprescribes the new drug Paregane, and everything changes. Soon Felix is also taking the drug, and they spend their nights roaming Paradise and conversing with Angels. One day he returns from work to discover her dead,of no apparent cause. In short order he loses his job and apartment and soon finds himself living in the wilds of upper Manhattan, addicted to Paregane, unable to find Veronica in Paradise, unable to die. Meanwhile,Dr. Bryson searches for a test subject. When she discovers Felix they are set on a course that will lead them deep into the Iroquois territories of upstate New York and a bloody struggle for survival.